Pharmacology · single question
A patient taking amitriptyline reports dry mouth. What is the mechanism?
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Correct answer: D. Anticholinergic (antimuscarinic) effects
Amitriptyline (TCA) has significant anticholinergic effects — blocks muscarinic M3 receptors on salivary glands, reducing secretion (xerostomia). Other anticholinergic effects: dry eyes, constipation, urinary retention, blurred vision.