Stevens-Johnson Syndrome (SJS) is most commonly associated with:

Stevens-Johnson Syndrome (SJS) is a severe, life-threatening mucocutaneous hypersensitivity reaction most commonly triggered by medications: sulfonamides (trimethoprim-sulfamethoxazole), anticonvulsants (carbamazepine, phenytoin, lamotrigine), allopurinol, NSAIDs, and antibiotics. It features painful erosions of at least two mucosal surfaces (oral, ocular, genital) and widespread epidermal detachment (<10% BSA). Drug allergy is the primary cause in adults. Infections (especially Mycoplasma, HSV) are more common triggers in children.