Micro & Immunology · single question
Which immunoglobulin mediates Type I (immediate) hypersensitivity?
Show answer and explanation
Correct answer: C. IgE
- A. Incorrect. IgG mediates Type II/III reactions.
- B. Incorrect. IgA is a mucosal antibody, not the mediator of Type I.
- C. Correct. IgE binds mast cells/basophils; allergen cross-linking triggers degranulation (histamine) — Type I immediate hypersensitivity/anaphylaxis.
- D. Incorrect. IgM is the first antibody in primary responses, involved in Type II/III, not Type I.
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