Pharmacology · single question

What is the mechanism of action of warfarin?

Patient on warfarin presents with an INR of 6.

  1. Vitamin K epoxide reductase inhibitor
  2. Direct thrombin inhibitor
  3. Factor Xa inhibitor
Show answer and explanation

Correct answer: A. Vitamin K epoxide reductase inhibitor

Warfarin = vitamin K antagonist. INR is the lab value used to monitor it.
  • A. Correct. Warfarin blocks vitamin K recycling, reducing synthesis of factors II, VII, IX, X. An INR of 6 reflects excessive anticoagulation.
  • B. That describes dabigatran, not warfarin.
  • C. That describes rivaroxaban/apixaban, not warfarin.

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