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Pharmacology · single question

What is the mechanism of action of bisphosphonates?

  1. They inhibit osteoclast function and promote osteoclast apoptosis, reducing bone resorption
  2. They stimulate osteoblast proliferation directly
  3. They inhibit the RANKL ligand as a monoclonal antibody
  4. They increase renal calcium excretion
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Correct answer: A. They inhibit osteoclast function and promote osteoclast apoptosis, reducing bone resorption

Bisphosphonates concentrate in bone and inhibit osteoclast-mediated resorption, in part by promoting osteoclast apoptosis, lowering bone turnover.Other options: Direct osteoblast stimulation is not their mechanism. RANKL inhibition describes denosumab. Increasing renal calcium excretion is not their mode of action.Key exam takeaway: Bisphosphonates = anti-resorptive via osteoclast inhibition/apoptosis; both they and denosumab are linked to MRONJ.

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