Pharmacology · single question

A drug like famotidine (Pepcid) has which mechanism of action?

  1. H2 receptor antagonist
  2. H1 receptor antagonist
  3. H2 receptor agonist
  4. H1 receptor agonist
Show answer and explanation

Correct answer: A. H2 receptor antagonist

  • A. Correct. Famotidine (Pepcid) and ranitidine belong to the H2 receptor antagonist class. They competitively block histamine H2 receptors on gastric parietal cells, reducing acid secretion.
  • B. H1 receptor antagonists are antihistamines used for allergy (e.g., diphenhydramine, cetirizine), not for acid suppression.
  • C. H2 agonists would stimulate acid production — the opposite of the therapeutic goal.
  • D. H1 agonists are not clinically used and would provoke allergic responses.

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