Pharmacology · single question
Which medication is associated with medication-related osteonecrosis of the jaw (MRONJ)?
Show answer and explanation
Correct answer: B. Denosumab
Denosumab (RANK-L inhibitor, antiresorptive) is strongly associated with MRONJ, similar to bisphosphonates.
- A. ❌ Methotrexate is not classically associated with MRONJ.
- B. ✅ CORRECT – Denosumab (Prolia/Xgeva) is a major MRONJ-associated antiresorptive drug.
- C. ❌ Prednisone is associated with avascular necrosis of the hip, not MRONJ specifically.
- D. ❌ Ibuprofen (NSAID) has no association with MRONJ.