Pharmacology · single question
What is the mechanism of action of lisinopril?
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Correct answer: A. ACE (angiotensin-converting enzyme) inhibitor, blocking conversion of angiotensin I to angiotensin II
Lisinopril is an ACE inhibitor, blocking the angiotensin-converting enzyme responsible for converting angiotensin I to the potent vasoconstrictor angiotensin II — reducing vasoconstriction and aldosterone-mediated sodium/water retention, thereby lowering blood pressure. ACE inhibitors classically cause a dry cough (from reduced bradykinin breakdown) and carry a risk of angioedema.