Which medication is a non-nicotine pharmacological aid for smoking cessation?

Bupropion is an atypical antidepressant (norepinephrine-dopamine reuptake inhibitor) that is FDA-approved as a non-nicotine aid for smoking cessation. It reduces nicotine cravings and withdrawal symptoms by modulating dopaminergic pathways in the brain's reward system. It is the only non-nicotine antidepressant approved for smoking cessation. The other approved non-nicotine medication is varenicline (Chantix). Nicotine patches, gum, and lozenges are nicotine replacement therapies (NRT), not non-nicotine aids.