Which drug is contraindicated with atorvastatin?

Clarithromycin is a strong CYP3A4 inhibitor, and atorvastatin (like simvastatin) is metabolized through CYP3A4 — combining them significantly raises statin blood levels and the risk of myopathy/rhabdomyolysis, which is why this combination is specifically flagged as a major interaction. Amoxicillin, metronidazole, and tetracycline do not share this strong CYP3A4-mediated interaction with atorvastatin.