Why is Methadone prescribed for opioid use disorder (morphine/heroin addiction)?

Methadone is a long-acting full opioid agonist (mu-receptor) with a half-life of 24-36 hours. Used in medication-assisted treatment (MAT) for opioid use disorder, it: (1) prevents withdrawal symptoms (long half-life provides stable plasma levels); (2) reduces cravings; (3) blocks the euphoric effects of illicit opioids; and (4) is dispensed under supervision, reducing diversion risk. Methadone does cause physical dependence, but its controlled administration improves patient stability and social functioning. Dental considerations: methadone is associated with xerostomia and sugar cravings (leading to rampant caries), and it prolongs the QT interval (cardiac monitoring needed).