Where is an ameloblastic fibroma MOST commonly located?

Correct answer: C. Posterior mandible

• A. Incorrect. The posterior maxilla is a rare site for this lesion.
• B. Incorrect. The anterior mandible is the classic site for the lateral periodontal cyst and for adenomatoid odontogenic tumour's mandibular counterpart — not ameloblastic fibroma.
• C. Correct. The ameloblastic fibroma is a true MIXED odontogenic tumour (both epithelium and ectomesenchyme are neoplastic) that arises overwhelmingly in the POSTERIOR MANDIBLE — the premolar/molar region. It occurs in a young age group (mean around 12–15 years, usually under 20), is typically a well-defined uni- or multilocular radiolucency, and is frequently associated with an unerupted tooth.
• D. Incorrect. The ANTERIOR MAXILLA is the classic location of the adenomatoid odontogenic tumour (the '2/3 tumour' — two-thirds female, two-thirds under 20, two-thirds anterior maxilla, two-thirds associated with a canine).

Note: Do not confuse with conventional ameloblastoma, which is also posterior mandible but occurs in an older cohort (30s–50s) and is locally aggressive. Ameloblastic fibroma is young, encapsulated and treated conservatively.