Pharmacology · single question

What is the mechanism of action of lisinopril, described in plain terms as inhibiting the narrowing of blood vessels?

  1. ACE inhibitor
  2. Direct vasodilator with no enzymatic mechanism
  3. Beta-blocker
  4. Calcium channel blocker
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Correct answer: A. ACE inhibitor

Lisinopril is an ACE (angiotensin-converting enzyme) inhibitor: it blocks the enzyme responsible for converting angiotensin I into angiotensin II, a potent vasoconstrictor — so blocking this conversion prevents that vasoconstriction ('inhibits the narrowing of blood vessels') and reduces aldosterone-mediated sodium/water retention, lowering blood pressure.

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