Pharmacology · single question

Primary cause of tissue necrosis following a local anesthetic injection?

  1. Tissue ischemia
  2. Allergic reaction
  3. Hemorrhage
  4. Infection
Show answer and explanation

Correct answer: A. Tissue ischemia

  • A. Correct. The vasoconstrictor (and high-pressure injection into attached tissue, e.g., palate) causes localized ischemia → necrosis.
  • B. Allergy causes hypersensitivity reactions, not localized necrosis.
  • C. Hemorrhage causes hematoma, not necrosis per se.
  • D. Infection is a rare separate complication, not the primary necrosis mechanism.

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