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Pharmacology · single question

A patient's medication list includes candesartan. What is the mechanism of action of this drug?

  1. Blocks the angiotensin II (AT1) receptor, preventing vasoconstriction and aldosterone release
  2. Blocks beta-1 adrenergic receptors, reducing heart rate and contractility
  3. Inhibits ACE, preventing conversion of angiotensin I to angiotensin II
  4. Inhibits HMG-CoA reductase, reducing cholesterol synthesis
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Correct answer: A. Blocks the angiotensin II (AT1) receptor, preventing vasoconstriction and aldosterone release

  • A. CORRECT. Candesartan is an angiotensin II receptor blocker (ARB). It specifically blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from exerting its effects (vasoconstriction, aldosterone release, sympathetic activation). Unlike ACE inhibitors, ARBs do NOT cause cough because they do not affect bradykinin metabolism.
  • B. Beta-blockers (e.g., metoprolol, atenolol) block adrenergic receptors. Candesartan acts on the renin-angiotensin system, not on beta receptors.
  • C. ACE inhibitors (e.g., lisinopril, enalapril) inhibit the enzyme that converts angiotensin I → angiotensin II. Candesartan is an ARB — it blocks the receptor DOWNSTREAM of angiotensin II formation.
  • D. HMG-CoA reductase inhibitors are statins (atorvastatin, rosuvastatin) used for hypercholesterolemia — not the mechanism of candesartan.

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