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Pharmacology · single question

Erythromycin causes drug interactions because it ___________________.

  1. Increases absorption of many drugs
  2. Decreases absorption of many drugs
  3. Decreases cytochrome P-450 metabolism of other drugs
  4. Increases renal reabsorption of many drugs
  5. Decreases distribution of many drugs
Show answer and explanation

Correct answer: C. Decreases cytochrome P-450 metabolism of other drugs

Erythromycin inhibits CYP3A4 (cytochrome P-450), preventing normal Phase I metabolism of co-administered drugs. This raises plasma concentrations to potentially toxic levels, causing serious interactions with antihistamines, statins, and warfarin.

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