Oral manifestations of Methotrexate therapy include all of the following EXCEPT:

Methotrexate causes oral ulceration/mucositis and stomatitis by inhibiting folate metabolism (dihydrofolate reductase inhibition), impairing rapidly dividing mucosal cells. Dental discoloration is NOT a recognized side effect of methotrexate. Discoloration is associated with tetracyclines, minocycline, fluoride excess, or trauma. Folinic acid (leucovorin rescue) is used to mitigate mucositis.