Pharmacology · single question
Which medication requires dose adjustment in chronic kidney disease?
Show answer and explanation
Correct answer: A. Amoxicillin
- A. Correct. Amoxicillin is renally excreted; dosing interval/amount must be reduced in significant renal impairment.
- B. Cephalexin is renally cleared too, but among these the keyed answer is amoxicillin as the classic dental example requiring adjustment.
- C. Clindamycin is hepatically metabolized and generally does not require renal dose adjustment.
- D. Tetracycline is avoided in renal disease (it can worsen azotemia) rather than simply dose-adjusted; doxycycline is the safer relative.