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Pharmacology · single question

Aspirin and clopidogrel affect which of the following?

  1. Platelet function
  2. Fibrinogen concentration
  3. Prothrombin time
  4. Platelet number
Show answer and explanation

Correct answer: A. Platelet function

  • A. Correct. Both are antiplatelet agents that impair platelet FUNCTION — aspirin irreversibly inhibits COX-1 (blocking thromboxane A2), and clopidogrel irreversibly blocks the P2Y12 ADP receptor. The platelet count remains normal.
  • B. Incorrect. Fibrinogen levels are unaffected by antiplatelet therapy.
  • C. Incorrect. PT/INR reflects the extrinsic coagulation cascade and is affected by warfarin, not antiplatelets.
  • D. Incorrect. Neither drug reduces the number of circulating platelets; that would be thrombocytopenia.

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