Long-term use of isoniazid (INH) for tuberculosis is associated with which complication?

Isoniazid (INH) long-term use causes: (1) Hepatotoxicity (most serious — monitor LFTs), (2) Peripheral neuropathy (prevented by pyridoxine/B6 supplementation), (3) Drug-induced lupus. Pyridoxine B6 is given with INH to prevent neuropathy. Hepatitis is the most clinically significant concern. Renal failure is not a primary association but 'all of the above' captures key toxicities.