Pharmacology · patient case question
A patient is taking isoniazid. What adverse effect should you anticipate?
Patient case: Systemic medication and pulp therapy
Scenario: Two short items.
Show answer and explanation
Correct answer: D. Hepatitis
- A. Ototoxicity belongs to the aminoglycosides and to streptomycin, another antitubercular agent.
- B. Pulmonary fibrosis is a recognised effect of bleomycin and amiodarone.
- C. Nephrotoxicity is characteristic of aminoglycosides and amphotericin B, not isoniazid.
- D. Correct. Isoniazid, used for tuberculosis, is well known for hepatotoxicity — with peripheral neuropathy from pyridoxine depletion as the other classic effect, which is why vitamin B6 is co-prescribed.
Note: Hepatotoxicity matters here directly: acetaminophen dosing must be reduced in a patient with compromised liver function.