Pharmacology · single question

Digoxin has many drug/food interactions. Which antibiotic is generally considered relatively SAFE to combine with digoxin?

  1. Tetracycline
  2. Clarithromycin
  3. Erythromycin
  4. Doxycycline
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Correct answer: D. Doxycycline

  • A. Incorrect – listed among interacting antibiotics for digoxin.
  • B. Incorrect – a macrolide that notably increases digoxin levels.
  • C. Incorrect – macrolides can increase digoxin levels (toxicity risk).
  • D. Correct (per the source set) – macrolides (erythromycin/clarithromycin) and some tetracyclines can raise digoxin levels by altering gut flora/absorption; doxycycline was identified as the safer pairing in this question.

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