Pharmacology · single question

What is the reversal agent for benzodiazepines such as Diazepam?

  1. Flumazenil
  2. Naloxone
  3. Atropine
  4. Protamine sulfate
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Correct answer: A. Flumazenil

Flumazenil (Romazicon) is a competitive benzodiazepine receptor antagonist that reverses the sedative, amnestic, and respiratory depressant effects of benzodiazepines. It competitively blocks GABA-A receptors at the benzodiazepine binding site. It has a shorter half-life than most benzodiazepines, so re-sedation can occur and repeat dosing may be needed. Naloxone is the reversal agent for opioids, not benzodiazepines. This distinction is critical in dental sedation emergencies.

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