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Pharmacology · single question

What effect do clopidogrel and aspirin have on the hematological system?

  1. Decrease platelet number
  2. Impair platelet function
  3. Inhibit vitamin K clotting factors
  4. Increase fibrinolysis
Show answer and explanation

Correct answer: B. Impair platelet function

  • A. Clopidogrel and aspirin do NOT decrease platelet count — they impair platelet FUNCTION. Thrombocytopenia is a different condition.
  • B. Aspirin (irreversibly inhibits COX-1, blocking thromboxane A2) and clopidogrel (irreversibly blocks P2Y12 ADP receptor on platelets) reduce platelet AGGREGATION. Platelet COUNT remains normal — only function is impaired. This is an antiplatelet effect.
  • C. Warfarin inhibits Vitamin K-dependent clotting factors (II, VII, IX, X). Aspirin and clopidogrel work on platelets, not clotting factors.
  • D. Aspirin and clopidogrel do not primarily enhance fibrinolysis. Fibrinolytics (like tPA) break down existing clots — a different mechanism.

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