Pathology · single question
A patient presents with vomiting and weight loss. A biopsy shows a cobblestone appearance of the mucosa. What is the most likely diagnosis?
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Correct answer: C. Crohn's disease (granulomatous inflammation)
- A. ❌ Sialolithiasis presents as salivary duct obstruction with swelling, not mucosal cobblestoning.
- B. ❌ Addison's disease is adrenal insufficiency causing bronze pigmentation, not cobblestone mucosa.
- C. ✅ Correct. Cobblestone appearance of the mucosa — caused by submucosal edema and ulceration — is the classic description of Crohn's disease (granulomatous bowel disease). It can have oral manifestations including cobblestone buccal mucosa.
- D. ❌ Leukoplakia is a white patch, not a cobblestone pattern on biopsy.