Pharmacology · single question
Why is antibiotic prophylaxis NOT recommended for patients with total joint replacement (hip/knee)?
Show answer and explanation
Correct answer: A. Lack of scientific evidence of effectiveness
✓ A) Lack of scientific evidence is correct.
The 2012/2014 ADA and AAOS joint statement and subsequent 2015 ADA evidence-based clinical practice guideline concluded that there is insufficient evidence that dental treatment causes prosthetic joint infections (PJI) and that prophylactic antibiotics reduce PJI risk. The practice of routine antibiotic prophylaxis for joint replacement patients undergoing dental procedures is NOT supported by evidence and may cause more harm (antibiotic resistance, side effects) than benefit. Each case should be individualized with orthopedic consultation for high-risk patients.
The 2012/2014 ADA and AAOS joint statement and subsequent 2015 ADA evidence-based clinical practice guideline concluded that there is insufficient evidence that dental treatment causes prosthetic joint infections (PJI) and that prophylactic antibiotics reduce PJI risk. The practice of routine antibiotic prophylaxis for joint replacement patients undergoing dental procedures is NOT supported by evidence and may cause more harm (antibiotic resistance, side effects) than benefit. Each case should be individualized with orthopedic consultation for high-risk patients.