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Pharmacology · single question

What is the primary mechanism of action of clonazepam?

  1. Enhances the release of GABA (Gamma-Aminobutyric Acid)
  2. Blocks the reuptake of serotonin in the brain
  3. Increases the production of dopamine in the central nervous system
  4. Enhances the inhibitory effects of GABA in the brain
Show answer and explanation

Correct answer: D. Enhances the inhibitory effects of GABA in the brain

Clonazepam is a benzodiazepine. Benzodiazepines bind to the GABA-A receptor and ALLOSTERICALLY ENHANCE the inhibitory effects of GABA — specifically they increase the FREQUENCY of chloride channel opening. They do NOT release GABA (A is wrong), do not block serotonin reuptake (SSRIs do — B is wrong), and do not increase dopamine (C is wrong). The key distinction: benzodiazepines enhance GABA's effect; they don't increase GABA release.

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