Pathology · single question
Which systemic condition is a classic cause of macroglossia in an adult?
Show answer and explanation
Correct answer: D. Amyloidosis
- A. Incorrect. Candidiasis produces erythema, pseudomembranes or atrophy of the papillae, not true enlargement of the tongue.
- B. Incorrect. Vitamin C deficiency (scurvy) causes gingival swelling, bleeding and poor wound healing.
- C. Incorrect. Antihypertensives are associated with gingival overgrowth (calcium channel blockers) and lichenoid reactions, not macroglossia.
- D. Correct. Amyloid deposition within the tongue musculature produces diffuse, firm enlargement — often with a nodular or 'pebbly' surface and lateral scalloping. It is a classic presenting sign of systemic amyloidosis, frequently secondary to multiple myeloma.