Pathology · single question

A patient presents with left-sided extraoral ulcers AND left intraoral ulcers following the same dermatomal distribution. What is the MOST likely cause?

  1. Erythema multiforme
  2. Aphthous stomatitis
  3. Herpes zoster (shingles)
  4. Herpes simplex type 1
Show answer and explanation

Correct answer: C. Herpes zoster (shingles)

  • A. Incorrect. Erythema multiforme causes bilateral oral ulcers and target skin lesions — not unilateral dermatomal.
  • B. Incorrect. Aphthous ulcers are oral only and do NOT follow dermatomal patterns or involve the skin.
  • C. Correct. Herpes zoster (VZV reactivation) characteristically presents with ulcers in a UNILATERAL DERMATOMAL distribution, affecting both skin and oral mucosa on the SAME SIDE. This dermatomal unilateral pattern is the hallmark of zoster.
  • D. Incorrect. HSV-1 causes perioral lesions but does NOT follow a strict unilateral dermatomal distribution.

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