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Pathology · single question

Which statement about HPV-positive oropharyngeal cancer is most accurate?

  1. It primarily affects men above 60 years old and has a poor prognosis
  2. It is now the most common cause of oropharyngeal cancer in the United States
  3. It is more common in women than men
  4. It is associated with tobacco use rather than sexual transmission
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Correct answer: B. It is now the most common cause of oropharyngeal cancer in the United States

HPV-positive oropharyngeal squamous cell carcinoma (HPV-OPC), caused primarily by HPV-16, has surpassed tobacco-related SCC as the most common cause of oropharyngeal cancer in the United States. Its incidence has risen dramatically since the 1980s, particularly in white middle-aged men aged 40–60 (not specifically above 60). HPV-OPC is predominantly associated with sexual transmission (especially oral sex). Compared to HPV-negative oropharyngeal cancers, HPV-positive tumors have a significantly better prognosis (higher 5-year survival rates). They typically arise at the base of tongue and tonsillar regions.

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