Pathology · single question
Which of the following is the most likely diagnosis for the delayed lesions (erythema, burning) around the mouth appearing 3 days after a latex reaction?
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Correct answer: D. Erythema multiforme
ERYTHEMA MULTIFORME (EM) is an immune-mediated reaction that can be triggered by infections (HSV most commonly) or drugs/allergens. It presents with 'target lesions' or iris lesions and can involve oral mucosa. In the context of a delayed hypersensitivity reaction to latex with burning oral/perioral lesions appearing 3 days later, erythema multiforme is the most likely diagnosis. Stevens-Johnson Syndrome is a severe form of EM (drug-induced) with systemic involvement.
- A. INCORRECT. Rosacea is a chronic facial skin condition (redness, papules, telangiectasias) — not a reaction to latex exposure.
- B. INCORRECT. Urticaria (hives) is an acute allergic reaction occurring within minutes — not delayed 3 days after exposure.
- C. INCORRECT. Stevens-Johnson Syndrome is a severe mucocutaneous drug reaction with extensive epidermal detachment and systemic toxicity — more severe than described.
- D. CORRECT. Erythema multiforme presents as an immune-mediated reaction occurring 1-3 weeks after a trigger, with characteristic target/iris lesions on skin and erosive oral ulcers. In the dental context, EM can be triggered by latex hypersensitivity, appearing days after exposure.