Which of the following increases the risk of pseudomembranous colitis?

Correct answer: A. Clindamycin

• A. Correct. Clindamycin carries the classically highest risk of triggering C. difficile-associated pseudomembranous colitis by disrupting normal gut flora.
• B. Penicillin can cause antibiotic-associated diarrhea but carries substantially lower risk than clindamycin.
• C. Tetracycline is a less common cause of C. difficile colitis compared to clindamycin.
• D. Amoxicillin can occasionally be implicated but is much less classically associated than clindamycin.