Pathology · single question
Which ingredient in denture adhesive can cause peripheral NEUROPATHY with excessive use?
Show answer and explanation
Correct answer: A. Zinc
Zinc in denture adhesives accumulates with excessive use, causing zinc toxicity → secondary copper deficiency → peripheral neuropathy/myelopathy.
- A. CORRECT. Zinc in denture adhesives can accumulate with excessive use, leading to zinc toxicity and secondary copper deficiency neuropathy. Zinc and copper compete for intestinal absorption sites. This led manufacturers to remove zinc from some formulations (zinc-free Fixodent).
- B. Sodium carboxymethylcellulose (CMC) is the primary adhesive polymer and is not associated with neuropathy.
- C. Polyvinylpyrrolidone is an adhesive agent without significant systemic toxicity at denture adhesive doses.
- D. Copper is not a component of denture adhesives. Paradoxically, zinc toxicity causes copper DEFICIENCY as the mechanism of neuropathy.