Pathology · single question

A smoker has a 3 mm ulcerated lesion on the lateral border of the tongue that has persisted for several weeks. What is the most appropriate management?

  1. Perform a biopsy — squamous cell carcinoma must be ruled out
  2. Reassure the patient and review in 6 months
  3. Prescribe a topical corticosteroid
  4. Start empirical antifungal therapy
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Correct answer: A. Perform a biopsy — squamous cell carcinoma must be ruled out

  • A. Correct. The lateral tongue is the most common intraoral site for squamous cell carcinoma, and a smoker with a persistent ulcer is high-risk. A persistent lesion (>2 weeks) requires biopsy.
  • B. Incorrect. Delaying diagnosis of a possible malignancy is dangerous; persistent lesions are not 'watched' for months.
  • C. Incorrect. Steroids treat inflammatory/immune lesions and could mask a malignancy without establishing a diagnosis.
  • D. Incorrect. There is nothing to suggest candidiasis; antifungals would only delay the needed biopsy.

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