Micro & Immunology · patient case question
Which immunoglobulin mediates allergic asthma?
Patient case: Hypersensitivity, asthma and research design
Scenario: Three items.
Show answer and explanation
Correct answer: D. IgE
- A. IgG is the most abundant serum immunoglobulin and the only one that crosses the placenta.
- B. IgM is the first antibody produced in a primary response and is the most efficient complement activator.
- C. IgA is the secretory antibody of mucosal surfaces and the dominant immunoglobulin in saliva, where it limits bacterial adherence.
- D. Correct. IgE binds mast cells and basophils; on re-exposure to allergen it triggers degranulation, bronchoconstriction and mucus secretion.
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