Micro & Immunology · single question

Which immunoglobulin is the PRIMARY antibody found in saliva?

  1. IgG
  2. IgE
  3. IgM
  4. Secretory IgA (sIgA)
Show answer and explanation

Correct answer: D. Secretory IgA (sIgA)

Secretory IgA (sIgA) is the predominant immunoglobulin in saliva, produced locally by plasma cells in salivary glands, protecting oral mucosa from pathogens.
  • A. ❌ IgG is the main serum immunoglobulin; not primary in saliva.
  • B. ❌ IgE mediates allergy; found in trace amounts.
  • C. ❌ IgM is the primary acute-phase serum antibody.
  • D. ✅ CORRECT – sIgA is the dominant salivary immunoglobulin.

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