Pharmacology · single question
Which drug should NOT be administered intravenously to a patient with known substance abuse history involving opioids?
Show answer and explanation
Correct answer: B. Fentanyl
- A. Ondansetron is an antiemetic with no opioid-like properties and can be used safely.
- B. Correct. Fentanyl is a potent synthetic opioid with high abuse potential. In patients with opioid substance abuse history, IV fentanyl should be avoided due to risk of re-triggering addiction and potential overdose. Non-opioid alternatives should be used instead.
- C. Midazolam (a benzodiazepine) is commonly used in IV sedation; while caution is warranted, it is not the primary concern for opioid abusers.
- D. Ketorolac is an NSAID with no abuse potential and is appropriate for opioid-tolerant patients.