Pharmacology · single question

Local anesthetics produce their effect primarily by acting on:

  1. Calcium influx
  2. Sodium channels
  3. Potassium efflux
  4. Acetylcholine receptors
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Correct answer: B. Sodium channels

  • A. Local anesthetics do not primarily block calcium channels.
  • B. Correct. Local anesthetics block voltage-gated sodium channels, preventing depolarization and nerve conduction.
  • C. Potassium efflux relates to repolarization, not the LA mechanism.
  • D. ACh receptors are the target of neuromuscular agents, not local anesthetics.

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