Which drug schedule is LEAST likely to cause abuse or dependence?

Schedule IV drugs have low potential for abuse and dependence relative to Schedule III. Examples: benzodiazepines (diazepam), tramadol, zolpidem. Schedule I has no accepted medical use and high abuse potential. Schedule II has high abuse potential (opioids, amphetamines). Schedule III has moderate potential (buprenorphine, combination opioids). IV < III < II < I for abuse potential.