Pharmacology · single question

What is the mechanism of action of fluoride?

  1. Increases calcium phosphate dissolution
  2. Decreases calcium phosphate dissolution (promotes remineralization)
  3. Kills bacteria by oxidation
  4. Blocks acid production
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Correct answer: B. Decreases calcium phosphate dissolution (promotes remineralization)

Fluoride DECREASES calcium phosphate dissolution and promotes remineralization by forming fluorapatite, which is more resistant to acid than hydroxyapatite. It also inhibits bacterial enzymes (enolase) reducing acid production. Option A is the opposite. Chlorhexidine kills bacteria (not fluoride's primary MOA). Fluoride's main role is remineralization.

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