Pathology · single question

Which disease is devoid of eosinophilic cells (no eosinophils in histology)?

  1. Aphthous ulcers
  2. Pemphigus Vulgaris
  3. Mucous membrane pemphigoid
  4. Eosinophilic ulcer
Show answer and explanation

Correct answer: A. Aphthous ulcers

APHTHOUS ULCERS (recurrent aphthous stomatitis) histologically show non-specific ulceration with a NEUTROPHIL-PREDOMINANT inflammatory infiltrate — there are NO significant eosinophils in the lesion. PEMPHIGUS VULGARIS shows intraepithelial vesicle with acantholysis (Tzanck cells). PEMPHIGOID shows subepithelial bulla with eosinophils in the infiltrate. Eosinophilic ulcer (traumatic eosinophilic granuloma) has ABUNDANT eosinophils by definition. Aphthous ulcers are devoid of eosinophils. A is correct.

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