Pathology · single question
Which disease is devoid of eosinophilic cells (no eosinophils in histology)?
Show answer and explanation
Correct answer: A. Aphthous ulcers
APHTHOUS ULCERS (recurrent aphthous stomatitis) histologically show non-specific ulceration with a NEUTROPHIL-PREDOMINANT inflammatory infiltrate — there are NO significant eosinophils in the lesion. PEMPHIGUS VULGARIS shows intraepithelial vesicle with acantholysis (Tzanck cells). PEMPHIGOID shows subepithelial bulla with eosinophils in the infiltrate. Eosinophilic ulcer (traumatic eosinophilic granuloma) has ABUNDANT eosinophils by definition. Aphthous ulcers are devoid of eosinophils. A is correct.