Pharmacology · single question
What neurochemical is associated with Alzheimer's disease?
Show answer and explanation
Correct answer: A. Acetylcholine (deficiency)
Alzheimer's disease is characterized by a significant DECREASE IN ACETYLCHOLINE due to degeneration of cholinergic neurons (especially in the nucleus basalis of Meynert). This is the CHOLINERGIC HYPOTHESIS of Alzheimer's. Treatment (Donepezil, Galantamine, Rivastigmine, Tacrine) works by INHIBITING ACETYLCHOLINESTERASE, thereby increasing available acetylcholine. This is why cognitive function temporarily improves with these medications. A (acetylcholine) is correct.