Pharmacology · single question
What is the primary mechanism of action of topical fluoride?
Show answer and explanation
Correct answer: C. Decreases calcium phosphate solubility (hydroxyapatite stabilization)
Fluoride's primary mechanism is decreasing hydroxyapatite solubility by converting it to fluorapatite, which is more acid-resistant.
- A. ❌ Fluoride does not significantly increase salivary flow.
- B. ❌ Fluoride promotes remineralization but its primary action is solubility reduction.
- C. ✅ CORRECT – Fluoride forms fluorapatite, making enamel more acid-resistant.
- D. ❌ Fluoride has antibacterial effects (enolase inhibition) but this is secondary.