A female patient taking estradiol is getting an extraction. All of the following are true EXCEPT:

Correct answer: C. Antibiotics can interfere with analgesics

• A. Estrogen-containing medications (OCP, HRT) DO increase the risk of dry socket — they affect fibrinolysis and clot stability. This statement IS TRUE.
• B. The traditional teaching was that antibiotics may reduce OCP efficacy (though current evidence shows this mainly applies to rifampicin). This caveat IS still taught. This IS true.
• C. Antibiotics CANNOT interfere with analgesics — this statement is FALSE and therefore is the EXCEPT answer. Antibiotics interact with oral contraceptives (by reducing their efficacy), warfarin, and methotrexate, but NOT with standard analgesics (acetaminophen, NSAIDs).
• D. Estrogens increase coagulation factor synthesis and can elevate thromboembolic risk. This IS TRUE.