Micro & Immunology · single question

What is the primary function of secretory IgA (sIgA) found in saliva?

  1. Antimicrobial defense
  2. Hemostasis
  3. Lubrication of oral tissues
  4. Initiating the complement cascade
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Correct answer: A. Antimicrobial defense

Secretory IgA (sIgA) is the predominant immunoglobulin in saliva and serves as the first line of immunological defense in the oral cavity. Its primary function is antimicrobial: it prevents microbial adhesion to mucosal surfaces (immune exclusion), neutralizes bacterial toxins and viruses, and inhibits bacterial colonization. sIgA is produced by plasma cells in salivary glands and is stabilized by a secretory component that protects it from proteolytic degradation in the oral environment. It is broader than simply 'antibacterial' as it also acts against viruses and fungi.

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