Micro & Immunology · single question
Which type of hypersensitivity reaction is responsible for SLE?
Show answer and explanation
Correct answer: B. Type III – Immune complex-mediated
SLE is primarily Type III hypersensitivity — immune complex (anti-dsDNA) deposition activates complement and causes inflammation in kidneys, joints, and skin.
- A. ❌ Type II targets cell surface antigens; examples include autoimmune hemolytic anemia.
- B. ✅ CORRECT – SLE: Type III; immune complex deposition + complement activation.
- C. ❌ Type I causes immediate allergic reactions (anaphylaxis); not SLE.
- D. ❌ Type IV is delayed T-cell mediated; causes contact dermatitis.
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