Public Health · single question
What is the MOST important factor determining the caries-preventive effectiveness of fluoride?
Show answer and explanation
Correct answer: D. Continuous low-level availability of fluoride ions in saliva and plaque
- A. High systemic intake risks fluorosis without adding proportional protection.
- B. Pre-eruptive incorporation into apatite produces fluorapatite but contributes far less than was once believed.
- C. Calcium availability supports remineralisation but is not the operative mechanism of fluoride.
- D. Correct. The modern understanding is that fluoride works predominantly TOPICALLY and POST-ERUPTIVELY. A CONSTANT low concentration of free fluoride ion in saliva and plaque fluid inhibits demineralisation at the crystal surface, promotes remineralisation with fluorapatite-like mineral, and inhibits bacterial enolase. This is why FREQUENCY of exposure beats concentration — twice-daily fluoride toothpaste outperforms occasional high-dose systemic delivery.