Pharmacology · single question

What is the most common side effect of buspirone (an anxiolytic)?

  1. Dizziness, nausea, and headache
  2. Respiratory depression
  3. Sedation and physical dependence
  4. Severe depression and suicidal ideation
Show answer and explanation

Correct answer: A. Dizziness, nausea, and headache

Buspirone is a non-benzodiazepine anxiolytic that acts as a partial agonist at serotonin 5-HT1A receptors. Unlike benzodiazepines, it does not cause sedation, physical dependence, or respiratory depression. The most common side effects of buspirone are dizziness, nausea, and headache — all typically mild and dose-dependent. Depression is listed as a rare side effect (occurs in <1% of patients). Buspirone is preferred over benzodiazepines in patients with substance abuse history because it has no addiction potential and does not cause significant CNS depression.

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