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Pharmacology · single question

What is the MOA of bisphosphonates?

  1. Stimulate osteoblast proliferation directly
  2. Bind hydroxyapatite in bone and induce osteoclast apoptosis, inhibiting bone resorption
  3. Block the RANKL receptor on osteoclast precursors
  4. Inhibit cyclooxygenase enzymes
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Correct answer: B. Bind hydroxyapatite in bone and induce osteoclast apoptosis, inhibiting bone resorption

Bisphosphonates are taken up preferentially at sites of active bone resorption, bind avidly to hydroxyapatite, and are internalized by osteoclasts, where nitrogen-containing bisphosphonates inhibit the mevalonate pathway, leading to osteoclast dysfunction and apoptosis.

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