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Pharmacology · single question

What is the MOA of levothyroxine, used for hypothyroidism?

  1. Blocks the thyroid hormone receptor
  2. Synthetic T4 that replaces endogenous thyroid hormone and is peripherally converted to active T3
  3. Inhibits thyroid peroxidase
  4. Stimulates pituitary TSH release
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Correct answer: B. Synthetic T4 that replaces endogenous thyroid hormone and is peripherally converted to active T3

Levothyroxine is bioidentical synthetic T4 (thyroxine). It is converted peripherally (mainly in the liver and kidney) to the more biologically active T3, restoring euthyroid metabolic status in hypothyroid patients.

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